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The relationship between religion and schizophrenia is of particular interest to psychiatrists because of the similarities between religious experiences and psychotic episodes; religious experiences often involve auditory and/or visual hallucinations, and those with schizophrenia commonly report similar hallucinations, along with a variety of beliefs that are commonly recognized by modern medical practitioners as delusional. In general, religion has been found to have "both a protective and a risk increasing effect" for schizophrenia.

A common report from those with schizophrenia is some type of religious belief that many medical practitioners consider to be delusional - such as the belief they are divine beings or prophets, that a god is talking to them, they are possessed by demons, etc. Active and adaptive coping skills in subjects with residual schizophrenia are associated with a sound spiritual, religious, or personal belief system.

Trans-cultural studies have found that such religious beliefs, which often may not be associated with reality, are much more common in patients with schizophrenia who identify as Christian and/or reside in predominately Christian areas such as Europe or North America. By comparison, patients in Japan much more commonly have delusions surrounding matters of shame and slander, and in Pakistan matters of paranoia regarding relatives and neighbors.

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