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The skull-and-crossbones symbol, consisting of a human skull and two bones crossed together behind the skull, is today generally used as a warning of danger of death, particularly in regard to poisonous substances.

The symbol, or some variation thereof, specifically with the bones below the skull, was also featured on the Jolly Roger, the traditional flag of European and American seagoing pirates. It is also part of the Canadian WHMIS home symbols placed on containers to warn that the contents are poisonous.

In the United States, due to concerns that the skull-and-crossbones symbol's association with pirates might encourage children to play with toxic materials, the Mr. Yuk symbol is also used to denote poison.

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