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Modified vaccinia Ankara is an attenuated strain of the vaccinia virus. It is being used as a vaccine against smallpox and monkeypox, having fewer side effects than the traditional smallpox vaccine.
This third-generation smallpox vaccine has the advantage that it cannot reproduce complete virions in human cells, "the block of the MVA life cycle occurs at the step of virion assembly resulting in assembly of immature virus particles that are not released from the infected cell."
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