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The illegal drug trade in Panama includes trans-shipment of cocaine to the United States. The 1989 United States invasion of Panama to topple Dictator Manuel Noriega was justified in part by the need to combat drug trafficking. Noriega, the dictator of Panama from 1983 to 1989, had a relationship with the U.S. Central Intelligence Agency from the 1950s. More recently, Mexican cartels such as the Sinaloa Cartel have been active in Panama.

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