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The first large-scale human trial of the birth control pill was carried out in Puerto Rico in the 1950s. Between conceptualization and legalization of the first birth control drug in the United States in 1960, there were many developments and trials of test drugs. One such trial happened in Puerto Rico in the 1950s. Before the drug was approved as safe in the mainland U.S., many Puerto Rican women were used as test subjects. The trials were conducted by Gregory Pincus and John Rock in 1955. These trials are a major component in the history of the development of female oral contraceptives, occurring in between initial small trial testing on the east coast and the release of the drug for public consumption.

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