What is Rate of infusion?

In pharmacokinetics, the rate of infusion refers not just to the rate at which a drug is administered, but the desired rate at which a drug should be administered to achieve a steady state of a fixed dose which has been demonstrated to be therapeutically effective.

Abbreviations include Kin, K0, or R0.

It can be calculated as the steady-state concentration in the plasma multiplied by the clearance:

K i n = C s s ⋅ C L {\displaystyle \textstyle K_{in}=C_{ss}\cdot CL}