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A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase , thereby preventing the inactivation of the intracellular second messengers, cyclic adenosine monophosphate and cyclic guanosine monophosphate by the respective PDE subtype. The ubiquitous presence of this enzyme means that non-specific inhibitors have a wide range of actions, the actions in the heart, and lungs being some of the first to find a therapeutic use.
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