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Spheroids of human autologous matrix-associated chondrocytes, sold under the brand name Spherox, is a medication used to repair defects to the cartilage in the knee in adults who are experiencing knee pain and problems moving the knee. It is used where the affected area is no larger than 10 cm.

The most common side effects include arthralgia and joint effusion , which can cause swelling of the joint.

Spherox contains spheroids of chondrocytes, cells found in healthy cartilage, that have been prepared from the patient's own tissues.

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