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Calcium citrate is the calcium salt of citric acid. It is commonly used as a food additive , usually as a preservative, but sometimes for flavor. In this sense, it is similar to sodium citrate. Calcium citrate is also found in some dietary calcium supplements. Calcium makes up 24.1% of calcium citrate and 21.1% of calcium citrate by mass. The tetrahydrate occurs in nature as the mineral Earlandite.

In 2019, it was the 225th most commonly prescribed medication in the United States, with more than 2 million prescriptions.

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