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Prostaglandin E is a family of naturally occurring prostaglandins that are used as medications.

Types include:

Both types are on the World Health Organization's List of Essential Medicines.

Prostaglandin E play an important role in thermoregulation of the human brain. Decreased formation of prostaglandin E through inhibition of cyclooxygenase is the basis for the antipyretic of nonsteroidal anti-inflammatory drugs.

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