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Salicylic acid is used as a medicine to help remove the outer layer of the skin. As such it is used to treat warts, skin tags, calluses, psoriasis, dandruff, acne, ringworm, and ichthyosis. For conditions other than warts, it is often used together with other medications. It is applied to the area affected.

Side effects include skin irritation, and salicylate poisoning. Salicylate poisoning tends to only occur when applied to a large area and in children. Use is thus not recommended in children less than two years old. It comes in a number of different strengths.

It is on the World Health Organization's List of Essential Medicines. It is also available mixed with coal tar, zinc oxide, or benzoic acid.

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