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EML4-ALK positive lung cancer is a primary malignant lung tumor whose cells contain a characteristic abnormal configuration of DNA wherein the echinoderm microtubule-associated protein-like 4 gene is fused to the anaplastic lymphoma kinase gene. This abnormal gene fusion leads to the production of a protein that appears, in many cases, to promote and maintain the malignant behavior of the cancer cells.
The transforming EML4-ALK fusion gene was first reported in non-small cell lung carcinoma in 2007.
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