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Tuberous sclerosis complex tumor suppressors form the TSC1-TSC2 molecular complex. Under poor growth conditions the TSC1-TSC2 complex limits cell growth. A key promoter of cell growth, mTORC1, is inhibited by the tuberous sclerosis complex. Insulin activates mTORC1 and causes dissociation of TSC from the surface of lysosomes.
Resistance to ischemia-reperfusion injury by protein restriction is mediated by activation of the tuberous sclerosis complex.
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