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In genetics, transcriptional amplification is the process in which the total amounts of messenger RNA molecules from expressed genes are increased during disease, development, or in response to stimuli.
At the subset of genes expressed in a given cell, the transcribing activity of RNA Polymerase II results in mRNA production. Transcriptional amplification is specifically defined as the increase in per-cell abundance of this set of expressed mRNAs. Transcriptional amplification is caused by changes in the amount or activity of transcription-regulating proteins.
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