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In medical testing with binary classification, the diagnostic odds ratio is a measure of the effectiveness of a diagnostic test. It is defined as the ratio of the odds of the test being positive if the subject has a disease relative to the odds of the test being positive if the subject does not have the disease.

The rationale for the diagnostic odds ratio is that it is a single indicator of test performance but which is independent of prevalence and is presented as an odds ratio, which is familiar to medical practitioners.

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