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Feline spongiform encephalopathy is a disease that affects the brains of felines. It is caused by proteins called prions. FSE is thought to be related or identical to bovine spongiform encephalopathy. This disease is known to affect domestic and captive feline species. This infectious agent might be spread by both haematogenous and nervous pathways. Like BSE, this disease can take several years to develop. It is probable, but not proven, that the affected animals contract the disease by eating contaminated bovine meat.

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