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Vesicular exanthema of swine virus is a virus which produces a disease in pigs that is clinically indistinguishable from the viruses causing foot-and-mouth disease and swine vesicular disease. VESV affects only pigs and marine mammals. It is not transmissible to humans.

VESV is only a concern among Californian pig-farmers; otherwise, the disease is now, by and large, a historical curiosity. It was globally eradicated in swine in 1959.

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