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Tumoral calcinosis is a rare condition in which there is calcium deposition in the soft tissue in periarticular location, around joints, outside the joint capsule. They are frequently seen in patients undergoing renal dialysis. Clinically also known as hyperphosphatemic familial tumoral calcinosis , is often caused by genetic mutations in genes that regulate phosphate physiology in the body ]. Best described genes that harbour mutations in humans are FGF-23, Klotho , or GALNT3. A zebrafish animal model with reduced GALNT3 expression also showed HFTC-like phenotype, indicating an evolutionary conserved mechanism that is involved in developing tumoral calcinosis.
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