What is Thermal amplitude (medical)?

Thermal amplitude or thermal range refers to the temperature range in which a cold autoantibody or cold-reacting alloantibody binds to its antigen. Cold antibodies that can bind to antigen above 30 °C are considered potentially clinically significant and may lead to disease that occurs or worsens on exposure to low temperatures. The closer the thermal range comes to core body temperature , the greater the chance that the antibody will cause symptoms such as anemia or Raynaud syndrome. Antibodies that are only reactive at temperatures below 30 °C are generally considered unlikely to be clinically significant.