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Anti-Scl-70 is an anti-topoisomerase antibody-type of anti-nuclear autoantibodies, seen mainly in diffuse systemic scleroderma , but is also seen in 10–18% of cases of the more limited form of systemic scleroderma called CREST syndrome. Anti Scl-70 antibodies are associated with more severe scleroderma disease.
The etymology of scl-70 consists of an abbreviation of scleroderma and a 70 kD extractable immunoreactive fragment that can be obtained from the otherwise larger target topoisomerase antigen of the antibodies.
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