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Primary pigmented nodular adrenocortical disease was first coined in 1984 by Carney et al. it often occurs in association with Carney complex. CNC is a rare syndrome that involves the formation of abnormal tumours that cause endocrine hyperactivity.
PPNAD arises due to the enlargement of the cortex of the adrenal glands, resulting in Cushing's syndrome that is independent of the pituitary hormone ACTH.
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