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Chronic fatigue syndrome is an illness with a long history of controversy. Many professionals within the medical community do not recognize CFS as a genuine condition, nor is there agreement on its prevalence. There has been much disagreement over the pathophysiology of chronic fatigue syndrome, how it should be diagnosed, and how to treat it.

The diagnosis is controversial, and its etiology is still not fully understood. Alternative names to describe the condition have been used over time throughout the world. Patient groups have criticized the name "chronic fatigue syndrome", saying that it trivializes the illness.

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