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CA 242 is a tumor marker for sialylated Lewis carbohydrates associated with adenocarcinomas and e-selectin-mediated metastatic risk. It is commonly tested along with CEA, CA19-9, and CA242 for detecting pancreatic cancer. The specificity of CA 242 is higher than similar markers. Current research dictates that diagnostic efficiency is highest when various tumor markers are tested for at once.

Ca242 has been used clinically a diagnostic biomarkers for pancreatic, colorectal and other cancers. Since Ca 242 is overexpressed in malignant tumor it is within reason to assume that Ca 242 could be a product of cancer cells. A study was conducted where Ca 242 serum levels where acquired from 34, 680 patients with 27 clinically defined diseases. The data acquired shows that patients with pancreatic, cervical and lymphoma had the highest levels of the Ca242 serum, which was followed by esophagus cancer, colon cancer and ovarian cancer. Ca 242 can be shown to detect other types of cancer as shown.

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