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A heavy isotope diet is one in that contains nutrients in which some atoms are replaced with their heavier non-radioactive isotopes, such as deuterium H or heavy carbon C. Biomolecules that incorporate heavier isotopes give rise to more stable molecular structures, which is hypothesized to increase resistance to damage associated with ageing or diseases.
Medicines with some hydrogen atoms substituted with deuterium are called deuterated drugs, while substances that are essential nutrients can be used as food constituents, making this food "isotopic". Consumed with food, these nutrients become building material for the body. The examples are deuterated polyunsaturated fatty acids, essential aminoacids, DNA bases such as cytosine, or heavy water and glucose.