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The Royal Commission on Animal Magnetism involved two entirely separate and independent French Royal Commissions, each appointed by Louis XVI in 1784, that were conducted simultaneously by a committee composed of four physicians from the Paris Faculty of Medicine and five scientists from the Royal Academy of Sciences , and a second committee composed of five physicians from the Royal Society of Medicine.

Each Commission took five months to complete its investigations. The "Franklin" Report was presented to the King on 11 August 1784 – and was immediately published and very widely circulated throughout France and neighbouring countries – and the "Society" Report was presented to the King five days later on 16 August 1784.

The "Franklin Commission's" investigations are notable as a very early "classic" example of a systematic controlled trial, which not only applied "sham" and "genuine" procedures to patients with "sham" and "genuine" disorders, but, significantly, was the first to use the "blindfolding" of both the investigators and their subjects.

Both sets of Commissioners were specifically charged with investigating the claims made by Charles d’Eslon for the existence of a substantial "animal magnetism", "le magnétisme animal", and of a similarly physical "magnetic fluid", "le fluide magnétique". Further, having completed their investigations into the claims of d'Eslon – that is, they did not examine Franz Mesmer, Mesmer's theories, Mesmer's principles, Mesmer's practices, Mesmer's techniques, Mesmer's apparatus, Mesmer's claims, Mesmer's "cures" or, even, "mesmerism" itself – they were each required to make "a separate and distinct report".

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