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Combined immunodeficiencies are immunodeficiency disorders that involve multiple components of the immune system, including both humoral immunity and cell-mediated immunity.
This category includes conditions such as bare lymphocyte syndrome, as well as severe combined immunodeficiency. Combined immunodeficiencies are commonly distinguished from SCID by low but not absent T-cell function.
ICD-9 divides immune deficiencies into three categories: humoral , cell-mediated , and combined. However, ICD-10 does not include a category for cell-mediated immune dysfunction , thus grouping T-cell mediated conditions with combined conditions.
peripheral: Purine nucleoside phosphorylase deficiency
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