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Wade Regehr, a Professor of Neurobiology at Harvard Medical School's Department of Neurobiology, developed a method to physiologically see the synaptic activity that occurs in the brain. A dye alters the fluorescence properties when attached to calcium. Using fluorescence-microscopy techniques calcium levels are detected, and therefore the influx of calcium in the presynaptic neuron. Regehr's laboratory specializes in pre-synaptic calcium dynamics which occurs at the axon terminals. Regehr studies the implication of calcium Ca as it affects synaptic strength. By studying the physiological process and mechanisms, a further understanding is made of neurological disorders such as epilepsy, schizophrenia and major depressive disorder, as well as memory and learning.