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The Pueblo Chemical Agent-Destruction Pilot Plant is a chemical weapons destruction facility built to destroy the chemical weapons stockpile stored at the U.S. Army Pueblo Chemical Depot , in southeastern Colorado. The depot contains munitions that are part of the U.S. national chemical weapons stockpile. Before chemical weapons destruction began at PCAPP, these munitions contained 2,613 U.S. tons of mustard agent. The weapons have been stored at the 23,000-acre depot since the 1950s.

The stockpile of chemical weapons originally stored at PCD consists of 155mm projectiles, 105mm projectiles and 4.2-inch mortar rounds. PCAPP is using neutralization followed by biotreatment to destroy the remaining stockpile in the main plant and Static Detonation Chamber technology to augment the main plant.

Destruction of this stockpile is a requirement of the Chemical Weapons Convention, an international treaty to which the United States is a party. The Organisation for the Prohibition of Chemical Weapons is the implementing body of the Chemical Weapons Convention and monitors the progress of the nation's chemical weapons destruction programs.

The Program Executive Office, Assembled Chemical Weapons Alternatives oversees the destruction of the Pueblo chemical weapons stockpile.

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