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The basal-like carcinoma is a recently proposed subtype of breast cancer defined by its gene expression and protein expression profile.
Since Preou et al. divided breast invasive carcinoma into 4 subtypes, Kapp et al. further compared multiple sets of cDNA microarray datasets, dividing breast cancer into five molecular subtypes, including luminal subtype A, luminal subtype B, normal breast-like subtype, HER-2 overexpression subtype] and basal-like Subtype. This marks the modern clinical pathological diagnosis of breast cancer has transferred from simple morphological diagnosis into morphological and molecular features combined diagnosis. Genotyping fundamentally changes the concept of breast cancer and provides breast cancer patients with more improved prognosis and treatment. In all molecular subtypes, basal-like breast cancer is still the biggest challenge in current research due to its strong invasiveness and molecular biological characteristics.