1 Answers
The miR-103 microRNA precursor , is a short non-coding RNA gene involved in gene regulation.miR-103 and miR-107 have now been predicted or experimentally confirmed in human.
microRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. In this case the mature sequence comes fromthe 5' arm of the precursor. The mature products are thought to have regulatory roles through complementarity to mRNA.
mir-103 and mir-107 were noted as being upregulated in obese mice and were subsequently found to have a key role in insulin sensitivity. This led to a suggestion that these microRNAs represent potential targets for the treatment of type 2 diabetes.
mir-103 has also been linked with chronic pain and intestinal cell proliferation.