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Prebediolone acetate , also known as 21-hydroxypregnenolone 21-acetate or 21-acetoxypregnenolone , as well as 3β,21-dihydroxypregn-5-en-20-one 21-acetate, is a synthetic pregnane steroid which is described as a glucocorticoid and has been used in the treatment of rheumatoid arthritis. It is the C21 acetate ester of prebediolone , the C21 hydroxylated derivative of pregnenolone. Prebediolone acetate has been known since at least 1950. The compound is also an intermediate in a synthesis of deoxycorticosterone acetate.

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