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A Chance fracture is a type of vertebral fracture that results from excessive flexion of the spine. Symptoms may include abdominal bruising , or less commonly paralysis of the legs. In around half of cases there is an associated abdominal injury such as a splenic rupture, small bowel injury, pancreatic injury, or mesenteric tear. Injury to the bowel may not be apparent in the first day.

The cause is classically a head-on motor vehicle collision in which the affected person is wearing only a lap belt. Being hit in the abdomen with an object like a tree or a fall may also result in this fracture pattern. It often involves disruption of all three columns of the vertebral body. The most common area affected is the lower thoracic and upper lumbar spine. A CT scan is recommended as part of the diagnostic work-up to detect any potential abdominal injuries. The fracture is often unstable.

Treatment may be conservative with the use of a brace or via surgery. The fracture is currently rare. It was first described by G. Q. Chance, a radiologist from Manchester, UK, in 1948. The fracture was more common in the 1950s and 1960s before shoulder harnesses became common.

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