What is Pelger–Huët anomaly?

Pelger–Huët anomaly is a blood laminopathy associated with the lamin B receptor, wherein several types of white blood cells have nuclei with unusual shape and unusual structure.

It is a genetic disorder with an autosomal dominant inheritance pattern. Heterozygotes are clinically normal, although their neutrophils may be mistaken for immature cells which may cause mistreatment in a clinical setting. Homozygotes tend to have neutrophils with rounded nuclei that do have some functional problems.