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Synthetic rescue refers to a genetic interaction in which a cell that is nonviable, sensitive to a specific drug, or otherwise impaired due to the presence of a genetic mutation becomes viable when the original mutation is combined with a second mutation in a different gene. The second mutation can either be a loss-of-function mutation or a gain-of-function mutation.
Synthetic rescue could potentially be exploited for gene therapy, but it also provides information on the function of the genes involved in the interaction
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