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Histamine intolerance, sometimes called histaminosis, is an over-accumulation of dietary histamine in the human body. Histamine intolerance is sometimes informally called an allergy; however, the intolerance is technically caused by the gradual accumulation of extracellular histamine due to an imbalance.

Roughly 1% of the population has histamine intolerance; of those, 80% are middle-aged.

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