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Lesbian, gay, bisexual, and transgender persons in São Tomé and Príncipe face legal challenges not experienced by non-LGBT residents. Both male and female same-sex sexual activity is legal in São Tomé and Príncipe, however LGBT persons face stigmatization among the broader population.

São Tomé and Príncipe was one of the few African states that signed a "joint statement on ending acts of violence and related human rights violations based on sexual orientation and gender identity" at the United Nations, condemning violence and discrimination against LGBT people.

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