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Microbicides for sexually transmitted diseases are pharmacologic agents and chemical substances that are capable of killing or destroying certain microorganisms that commonly cause human infection.
Microbicides are a diverse group of chemical compounds that exert their activity by a variety of different mechanisms of action. Multiple compounds are being developed and tested for their microbicidal activity in clinical trials. Microbicides can be formulated in various delivery systems including gels, creams, lotions, aerosol sprays, tablets or films and sponges and vaginal rings over a longer period]. Some of these agents are being developed for vaginal application, and for rectal use by those engaging in anal sex.
Although there are many approaches to preventing sexually transmitted diseases in general , current methods have not been sufficient to halt the spread of these diseases. Sexual abstinence is not a realistic option for women who want to bear children, or who are at risk of sexual violence. In such situations, the use of microbicides could offer both primary protection and secondary protection. It is hoped that microbicides may be safe and effective in reducing the risk of HIV transmission during sexual activity with an infected partner.