A newborn is presented with a bloated abdomen shortly after birth with passing of less meconium. A full thickness biopsy of the rectum was carried out. Which one of the following rectal biopsy findings is most likely to be present?

Option 3 : Lack of ganglion cells

Concept-

• The failure of passing meconium in first 24 hours may be a sign of medical condition such as intestinal obstruction.
• The baby passes stool the meconium is passes out of their body

Stimulate the baby to bowel’s by doing the following:

• Bend their knees towards their chest.
• Gently massage their abdomen.
• Give him warm bath for relax muscles.

Explanation-

• The absence of ganglion cell leaves the affected portion of intestine paralyzed and unable to propagate stool.
• Hirschsprung disease is a birth defect. This disorder is characterized by the absence of ganglion cell
• The absence of ganglion cell causes the muscles in the bowel to lose their ability to move stool through intestine.

• Muscular propria thickened – thickened muscular propria was define as being present when width of muscular interna and externa of small intestine.
• Hyalinisation of muscular coat -  a condition in which normal tissue deteriorates into a homogenous translucent material.
• Fibrosis of submucosa – fibrosis submucosa characterized by abnormal collagen deposition.it is precancerous disorder and transform into malignant