Ballon d'Or: 2009[400]
FIFA World Player of the Year: 2009[400]
UEFA Club Footballer of the Year: 2009[401]
UEFA Club Forward of the Year: 2009[401]
FIFA Ballon d'Or: 2010, 2011, 2012, 2015[400]
IFFHS World's Best Top Goalscorer: 2011, 2012[402]
IFFHS World's Best Top Division Goalscorer: 2012, 2013[402]
IFFHS World's Best Playmaker: 2015[403]
UEFA Best Player in Europe: 2011, 2015[190]
European Golden Shoe: 2010, 2012, 2013[149]
La Liga Best Player: 2009, 2010, 2011, 2012, 2013, 2015[404][405][406]
La Liga Best Forward: 2009, 2010, 2011, 2012, 2013, 2015[404][405][406]
La Liga Player of the Month: January 2016[407]
Olimpia de Plata (Argentine Footballer of the Year): 2005, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2015[404][408]
Olimpia de Oro (Argentine Sportsperson of the Year): 2011[404]
FIFA Club World Cup Golden Ball: 2009, 2011[409]
FIFA Club World Cup Silver Ball: 2015[410]
FIFA World Cup Golden Ball: 2014[411]
Copa América Most Valuable Player: 2015 (rejected)[276]
FIFA FIFPro World XI: 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015[412][413]
UEFA Team of the Year: 2008, 2009, 2010, 2011, 2012, 2014, 2015[401][414]
La Liga Team of the Year: 2015[415]
AFA Team of All Time (published 2015)[416]
FIFA World Cup Dream Team: 2014[417]
Copa América Dream Team: 2007, 2011, 2015, 2016[418][419][420][293]
UEFA Goal of the Year: 2007, 2015[404][185]
Copa América Best Goal: 2007[421][422]
FIFPro Young World Player of the Year: 2006, 2007, 2008[412]
Golden Boy (Young European Footballer of the Year): 2005[47]
FIFA World Youth Championship Golden Ball: 2005[423]
FIFA World Youth Championship Golden Shoe: 2005[423]
Copa América Best Young Player: 2007[412]
La Liga top goalscorer: 2009–10, 2011–12, 2012–13[424]
La Liga top assist provider: 2010–11, 2014–15, 2015–16[425]
Copa del Rey top goalscorer: 2008–09, 2010–11, 2013–14, 2015–16[426]
UEFA Champions League top goalscorer: 2008–09, 2009–10, 2010–11, 2011–12, 2014–15[427]
UEFA Champions League top assist provider: 2011–12, 2014–15[428]
FIFA Club World Cup top goalscorer: 2011[429]
FIFA World Youth Championship top goalscorer: 2005[214]
Copa América top assist provider: 2011, 2015, 2016