Aluminium Hydroxide + Magnesium Hydroxide Uses, Dosage, Side Effects

Generic Name	Aluminium Hydroxide + Magnesium Hydroxide
Bangla Name	অ্যালুমিনিয়াম হাইড্রক্সাইড + ম্যাগনেসিয়াম হাইড্রক্সাইড
Available brands	49
Language	English বাংলা

Generic Name

Aluminium Hydroxide + Magnesium Hydroxide

Bangla Name

অ্যালুমিনিয়াম হাইড্রক্সাইড + ম্যাগনেসিয়াম হাইড্রক্সাইড

Available brands

Language

English বাংলা

Introduction

Aluminium Hydroxide and Magnesium Hydroxide are antacids combinations commonly used to treat occasional heartburn, indigestion, and excessive stomach acid. This medication works by neutralizing acid in the stomach and helps to provide relief from symptoms associated with acid reflux. This medication comes in tablets and capsule forms for oral consumption only.

Uses

Aluminium Hydroxide and Magnesium Hydroxide are commonly used to relieve occasional heartburn and excess acid production in the stomach. It helps to reduce acidity levels in the body and relieves symptoms of upset stomach, heartburn and indigestion. This medication is also used to treat other medical conditions as prescribed by the doctor.

Mechanism of Action

Aluminium Hydroxide and Magnesium Hydroxide are combinations of direct-acting antacids. When taken orally, this medication reaches the stomach and reacts with the acid present in the stomach. This reaction helps to lower the acidity levels and neutralize the stomach acid. As a result, the patient experiences relief from the symptoms of heartburn and indigestion.

How Long Does It Take to Work?

The effect of aluminium hydroxide and magnesium hydroxide begins within 15 minutes of taking the medication and usually lasts for three to four hours. The length of the effect may vary depending on the dosage of the drug consumed and the degree of acidity in the stomach.

Absorption

Aluminium Hydroxide and Magnesium Hydroxide are not generally absorbed in the body when taken orally. This medication does not travel further than the stomach and stays there until it is eliminated from the body.

Route of Elimination

Aluminium Hydroxide and Magnesium Hydroxide is eliminated from the body by the digestive system. The medication is eliminated from the body through faeces.

Dosage

The recommended dose of Aluminium Hydroxide and Magnesium Hydroxide falls between 200mg to 800mg per dose. The doctor may adjust the dosage depending on the severity of symptoms. Usually, this medication should be taken 2-3 times a day as prescribed by the doctor.

Administration

Aluminium Hydroxide and Magnesium Hydroxide should be taken orally with a full glass of water. This medication should be taken with or without food as prescribed by the doctor. It is important to follow the instructions on the label carefully and take the medication as directed.

Side Effects

Common side effects of Aluminium Hydroxide and Magnesium Hydroxide include abdominal distress, nausea, dyspepsia, constipation, diarrhoea, and vomiting. Some patients may experience an allergic reaction after taking this medication. It is important to seek medical help if you experience any serious side effects.

Toxicity

Aluminium Hydroxide and Magnesium Hydroxide is generally safe and well tolerated. This medication has a low toxicity level and is safe when taken at recommended doses. However, taking higher than recommended doses may increase the risk of toxicity.

Precaution

It is important to follow all the directions given by the doctor while taking Aluminium Hydroxide and Magnesium Hydroxide. This medication may interfere with other medicines, such as mineral supplements or digestive enzymes. It is important to discuss your medical history with your healthcare provider before taking this medication.

Interaction

Aluminium Hydroxide and Magnesium Hydroxide may interact with other medications such as antibiotics, antifungal medicines, anti-inflammatory medicines, and anticoagulants. It is important to inform your healthcare provider of all the medicines you are taking before taking this medication.

Disease Interaction

Aluminium Hydroxide and Magnesium Hydroxide may interact with certain medical conditions. It is important to inform your healthcare provider of any existing medical condition before taking this medication. This medication may interact with kidney disease, magnesium deficiency, and bladder problems.

Drug Interaction

Aluminium Hydroxide and Magnesium Hydroxide may interact with certain drugs such as ciprofloxacin, tetracyclines, cyclosporine, fluconazole, omeprazole, and levodopa. It is important to inform your healthcare provider of all the drugs you are taking before taking this medication. This medication may interact with antacids, iron supplements, and biphosphonates.

Food Interactions

Aluminium Hydroxide and Magnesium Hydroxide may interact with certain food or beverages. It is important to discuss your diet with your healthcare provider before taking this medication. This medication may interact with high-calcium foods, dairy products, and calcium-containing juices.

Pregnancy Use

Aluminium Hydroxide and Magnesium Hydroxide should be used with caution in pregnant women. This medication may pass into breast milk and could cause harm to a nursing infant. It is important to discuss your pregnancy and medical history with your healthcare provider before taking this medication.

Lactation Use

Aluminium Hydroxide and Magnesium Hydroxide should be used with caution in nursing mothers. This medication may pass into breast milk and could cause harm to a nursing infant. It is important to discuss your breastfeeding and medical history with your healthcare provider before taking this medication.

Acute Overdose

If an acute overdose of Aluminium Hydroxide and Magnesium Hydroxide is suspected, contact your local poison control center right away. The symptoms of an acute overdose can include metallic taste in the mouth, nausea, vomiting, abdominal pain, diarrhea, muscle weakness, and slowed breathing.

Contraindication

Aluminium Hydroxide and Magnesium Hydroxide should not be used by patients who are hypersensitive or allergic to the components of the medication. This medication should also not be used by patients who have any underlying medical conditions such as kidney disease or impaired renal function.

Use Direction

Aluminium Hydroxide and Magnesium Hydroxide should always be taken as recommended by the doctor. This medication should be taken with a full glass of water. It is important to follow the directions on the label carefully and take the medication as prescribed.

Storage Condition

Aluminium Hydroxide and Magnesium Hydroxide should be stored at room temperature away from light and moisture. Keep this medication out of reach of children and away from pets.

Volume of Distribution

Aluminium Hydroxide and Magnesium Hydroxide is not significantly distributed in the body when taken orally. This medication does not reach beyond the stomach and hence, it is not subject to volume of distribution.

Half Life

The half life of Aluminium Hydroxide and Magnesium Hydroxide is not known. This medication does not reach beyond the stomach and is eliminated from the body through the digestive system.

Clearance

Aluminium Hydroxide and Magnesium Hydroxide is not cleared from the body and is instead eliminated directly through the digestive system. This medication is not cleared by the kidneys and does not accumulate in the body.

Frequently Asked Questions About Aluminium Hydroxide + Magnesium Hydroxide

1. What is Aluminium Hydroxide + Magnesium Hydroxide?

Aluminium Hydroxide + Magnesium Hydroxide is a combination antacid medication used to neutralize stomach acid and relieve symptoms of heartburn, acid indigestion, and upset stomach. It is commonly found in over-the-counter (OTC) products like Maalox, Mylanta, or generic formulations, available as tablets, chewable tablets, or liquid suspensions.

2. What class of drug does this combination belong to?

This combination belongs to the class of antacids. Antacids work by directly neutralizing excess hydrochloric acid in the stomach, providing quick relief from acid-related discomfort without affecting acid production like other drugs (e.g., proton pump inhibitors).

3. How does Aluminium Hydroxide + Magnesium Hydroxide work?

The two components work together to neutralize stomach acid:

Aluminium Hydroxide: Reacts with hydrochloric acid to form aluminium chloride and water, reducing acidity.
Magnesium Hydroxide: Combines with acid to form magnesium chloride and water, also neutralizing acid.

Their combined action balances their individual side effects (constipation from aluminium, diarrhea from magnesium) while providing fast relief.

4. What conditions does this combination treat?

It is used to treat:

Heartburn: Burning sensation from acid reflux.
Acid indigestion: Discomfort from excess stomach acid.
Sour stomach: General upset due to acidity.
Peptic ulcer symptoms: Temporary relief of pain (not a cure).

It’s a symptomatic treatment, not a cure for underlying conditions.

5. Is this combination used for anything other than stomach acid?

Primarily, it’s an antacid, but Aluminium Hydroxide is sometimes used in higher doses to lower phosphate levels in patients with kidney disease (as a phosphate binder). This is less common with the combination, which is mainly for acid relief.

6. How is Aluminium Hydroxide + Magnesium Hydroxide taken?

It’s taken orally as a liquid suspension, chewable tablet, or regular tablet. Chewable tablets should be thoroughly chewed before swallowing, and liquids should be shaken well. It’s typically taken after meals or when symptoms occur, following package or doctor instructions.

7. What is the typical dosage for adults?

Dosage varies by formulation, but a common dose is 10–20 mL of liquid or 2–4 chewable tablets (containing 200–400 mg of each ingredient per dose), taken 1–4 times daily as needed, usually after meals and at bedtime. Do not exceed the maximum daily dose (often 80 mL or 16 tablets) unless advised by a doctor.

8. What is the dosage for children?

For children, dosing depends on age and weight and should be determined by a doctor. For example, children 6–12 years might take half the adult dose (5–10 mL or 1–2 tablets), but it’s not typically recommended for those under 6 without medical advice.

9. Can it be taken with food?

It’s usually taken after meals or when symptoms arise, not with food directly. Taking it post-meal helps neutralize acid produced during digestion, enhancing its effectiveness for heartburn or indigestion.

10. What should I do if I miss a dose?

Since it’s taken as needed, there’s no strict schedule. If you miss a dose and still have symptoms, take it when you remember. Don’t double up, as it’s not a maintenance drug but a symptom-reliever.

11. How quickly does it work?

It works within minutes—typically 5–15 minutes—by directly neutralizing stomach acid. Relief is fast but temporary, lasting 1–3 hours, depending on the meal and acid production.

12. What are the common side effects?

Common side effects include:

Constipation: From Aluminium Hydroxide, which slows bowel movements.
Diarrhea: From Magnesium Hydroxide, which has a laxative effect.
Chalky taste: A mild, temporary aftertaste.

The combination aims to balance these effects, but they can still occur.

13. What are the serious side effects?

Serious side effects are rare with short-term use but include:

Electrolyte imbalance: High magnesium or aluminium levels with prolonged use.
Kidney issues: Aluminium buildup in patients with renal failure.
Bowel obstruction: From severe constipation (very rare).

Seek medical help if symptoms like confusion or severe abdominal pain occur.

14. Why does it cause constipation or diarrhea?

Aluminium Hydroxide binds water in the intestines, slowing motility and causing constipation. Magnesium Hydroxide draws water into the intestines, speeding motility and causing diarrhea. The combination minimizes these extremes, but individual responses vary.

15. Can it cause stomach upset?

It’s designed to relieve stomach upset, so it rarely causes it. However, overuse or sensitivity might lead to bloating or mild discomfort due to gas from acid neutralization (producing carbon dioxide).

16. Who should not take this combination?

It’s not suitable for:

People with kidney disease: Risk of aluminium or magnesium buildup.
Those allergic to ingredients: Rare but possible hypersensitivity.
Patients with bowel obstruction: Due to constipation risk.

Consult a doctor if you have these conditions.

17. Is it safe during pregnancy?

It’s generally considered safe in pregnancy for occasional use, as it’s not absorbed systemically in significant amounts. However, prolonged use may affect electrolyte balance, so pregnant women should consult a doctor first.

18. Can I take it while breastfeeding?

Yes, it’s safe during breastfeeding since minimal amounts enter breast milk. Still, avoid excessive use and check with a healthcare provider for long-term needs.

19. Does it interact with other medications?

Yes, it can reduce absorption of:

Antibiotics: Like tetracycline or fluoroquinolones.
Iron supplements: Binds to iron, reducing uptake.
Other drugs: E.g., digoxin or levothyroxine.

Take it 2 hours before or after other medications to avoid interactions.

20. Can I drink alcohol while taking it?

Alcohol doesn’t directly interact with it, but it can worsen acid reflux or stomach irritation, counteracting the antacid’s benefits. Limit alcohol if using it for heartburn.

21. Does it cause weight gain?

No, it doesn’t affect metabolism or cause weight gain. Any perceived change might be due to bloating or water retention from altered bowel habits.

22. Can it be taken at night?

Yes, it’s often taken at bedtime to relieve nighttime heartburn or acid reflux, especially after a late meal. It can help you sleep better by reducing discomfort.

23. How long can I take it?

It’s safe for occasional use (up to 2 weeks) without a doctor’s advice. Longer use risks side effects like electrolyte imbalances or kidney strain, so consult a doctor if symptoms persist.

24. Can I stop taking it suddenly?

Yes, since it’s taken as needed, stopping poses no withdrawal risk. However, acid symptoms may return if the underlying cause (e.g., diet or GERD) isn’t addressed.

25. Does it affect blood sugar?

No, it doesn’t influence blood sugar levels. It acts locally in the stomach and isn’t absorbed enough to affect systemic metabolism.

26. Can it cause high magnesium or aluminium levels?

Yes, with prolonged use or in kidney disease, magnesium (hypermagnesemia) or aluminium (aluminosis) can accumulate, causing symptoms like weakness or confusion. This is rare with normal use.

27. What should I avoid while taking it?

Avoid:

Other medications too close in time: Space them out.
Excessive dairy: May increase calcium-related side effects.
High-acid foods: Like citrus or spicy meals, if treating reflux.

28. Can it cause fatigue?

Fatigue isn’t a direct side effect. If it occurs, it might relate to electrolyte changes from overuse or the underlying condition causing acid issues.

29. Is it safe for elderly patients?

Yes, but the elderly with reduced kidney function should use it cautiously and avoid long-term use without monitoring, due to risks of aluminium or magnesium buildup.

30. Does it affect the liver?

No, it’s not metabolized by the liver and acts locally in the stomach. Liver effects are negligible unless there’s pre-existing severe disease.

31. Can it be used in children?

Yes, but only under medical supervision for children under 12. Doses are lower and adjusted for age and weight to avoid side effects.

32. What’s the maximum daily dose?

Typically, it’s 80 mL of liquid or 16 tablets (depending on strength, e.g., 200–400 mg of each per dose), not to exceed 4 doses in 24 hours unless a doctor advises otherwise.

33. Can it cause bloating?

Yes, neutralizing acid produces carbon dioxide gas, which may cause mild bloating or belching in some people, though this is usually temporary.

34. How is it different from other antacids?

Compared to calcium carbonate (e.g., Tums), it’s less likely to cause rebound acid production. The aluminium-magnesium mix balances bowel effects better than single-ingredient antacids.

35. Can it prevent stomach ulcers?

No, it relieves ulcer symptoms but doesn’t heal or prevent them. Drugs like PPIs or H2 blockers are needed for ulcer treatment.

36. Does it affect cholesterol?

No, it has no impact on cholesterol levels, as it works only in the digestive tract and isn’t absorbed systemically.

37. Can it be taken with other antacids?

It’s not usually necessary, as it’s already a combination. Combining with others (e.g., calcium-based antacids) could increase side effect risks without added benefit.

38. What tests should I get if using it long-term?

For prolonged use, check:

Kidney function: Creatinine levels.
Electrolytes: Magnesium, aluminium, calcium.

This ensures no buildup or imbalance occurs.

39. Can it cause mood changes?

No, it doesn’t affect the brain or mood, as it’s not absorbed into the bloodstream significantly.

40. Is it addictive?

No, it’s not habit-forming. However, frequent use might mask a serious condition needing medical attention.

41. Can it be chewed or crushed?

Chewable tablets are meant to be chewed. Regular tablets shouldn’t be crushed unless specified, and liquid forms don’t require alteration.

42. Does it cause hair loss?

No, there’s no evidence linking it to hair loss. Any such effect would be unrelated or due to another cause.

43. Can it be used for nausea?

It’s not specifically for nausea but may help if nausea is due to acid indigestion. Other causes (e.g., motion sickness) won’t respond.

44. What’s the shelf life?

Typically, 2–3 years from manufacture, but check the expiration date. Expired antacids may lose potency but aren’t harmful.

45. Can it cause a rash?

A rash is rare but possible if allergic to an ingredient. Discontinue use and see a doctor if it occurs.

46. Does it affect exercise?

No direct effect, but relieving acid reflux might improve comfort during exercise. Overuse could cause bowel changes affecting activity.

47. Can it be taken with aspirin?

Yes, but take it 2 hours apart, as it may reduce aspirin absorption. It can also help ease stomach irritation from aspirin.

48. Is it expensive?

No, it’s an affordable OTC medication, with generics costing a few dollars for a bottle or pack, depending on region.

49. Can it cause bad breath?

No, it doesn’t cause bad breath. A chalky aftertaste might be noticed, but it’s temporary.

50. How should it be stored?

Store at room temperature (15–30°C or 59–86°F), away from heat, moisture, and direct sunlight. Keep liquid forms tightly closed and shake before use.

Medical review

Last reviewed: 30 Aug 2024

Medically reviewed by:

This is general information, not personal medical advice. Consult a doctor before taking any medicine.