Brand Name Zytix
Type Tablet
Weight 250 mg
Generic Abiraterone Acetate
Manufacturer Beacon Pharmaceuticals Ltd.
Price (Bangladesh) Unit: ৳ 580.00 (1 x 6: ৳ 3,480.00) Strip: ৳ 3,480.00
Available in

About Zytix Tablet 250 mg

Zytix Tablet 250 mg is a brand medicine manufactured by Beacon Pharmaceuticals Ltd. containing the generic Abiraterone Acetate (250 mg). Current listed price in Bangladesh: Unit: ৳ 580.00 (1 x 6: ৳ 3,480.00) Strip: ৳ 3,480.00.

Medical information for Zytix Tablet 250 mg

Uses, dosage, side effects, and safety details below apply to Zytix Tablet 250 mg (generic: Abiraterone Acetate). This is general information — consult a doctor before use.

Introduction

Abiraterone is a derivative of steroidal progesterone and is an innovative drug that offers clinical benefit to patients with hormone refractory prostate cancer. Abiraterone is administered as an acetate salt prodrug because it has a higher bioavailability and less susceptible to hydrolysis than abiraterone itself.

Uses

Abiraterone is an antiandrogen used in the treatment of prostate cancer.

Used in combination with prednisone for the treatment of metastatic, castration-resistant prostate cancer.

Associated Conditions

  • Metastatic Castration Resistant Prostate Cancer

Pharmacodynamics

Abiraterone is associated with decreases in PSA levels, tumor shrinkage (as evaluated by RECIST criteria), radiographic regression of bone metastases and improvement in pain. Levels of adrenocorticotropic hormones increased up to 6-fold but this can be suppressed by dexamethasone.

Mechanism of Action

Abiraterone is an orally active inhibitor of the steroidal enzyme CYP17A1 (17 alpha-hydroxylase/C17,20 lyase). It inhibits CYP17A1 in a selective and irreversible manner via covalent binding mechanism. CYP17A1 is an enzyme that catalyzes the biosynthesis of androgen and is highly expressed in testicular, adrenal, and prostatic tumor tissue. More specifically, abiraterone inhibits the conversion of 17-hydroxyprognenolone to dehydroepiandrosterone (DHEA) by the enzyme CYP17A1 to decrease serum levels of testosterone and other androgens.

Absorption

Abiraterone itself is poorly absorbed and is susceptible to hydrolysis by esterases. The salt form, abiraterone acetate, is a prodrug which has a much higher oral bioavailability and is also esterase resistant. Peak drug concentrations of abiraterone were reached in 1.5 - 4 hours. Abiraterone acetate was rapidly and completely deacetylated into abiraterone-the parent salt form was not detectable in early pharmacokinetic studies. Food and high fat meals increases absorption 4.4-fold.

Volume of Distribution

Vdss= 19,669 ± 13,358 L

Protein Binding

>99% protein bound to alpha-1-acid glycoprotein and albumin.

Route of Elimination

Excreted via feces (~88%) and urine (~5%)

Half Life

Terminal elimination half-life = 5-14 hours

Toxicity

Toxicity is related to the blockade of 17α-hydroxylase activity. Blockade results in the accumulation of upstream mineralocorticoids like 11-deoxycorticosterone leading to secondary hyperaldosteronism. Signs of hydroaldosteronism include fluid retention and hypokalemia. Mineralocorticoid receptor antagonists may be used to treat signs and symptoms.

Food Interactions

  • Exercise caution with St. John's Wort. This herb induces CYP3A4 and may increase the serum levels of abiraterone.
  • Take on an empty stomach. Take at least 1 hour before or 2 hours after eating as food may increase exposure to abiraterone by 4-fold.

Frequently Asked Questions About Zytix Tablet 250 mg

1. What is Zytix Tablet 250 mg?

Zytix Tablet 250 mg is a medication used in the treatment of metastatic castration-resistant prostate cancer (mCRPC). It works by inhibiting androgen production, which helps to slow cancer growth.

2. How does Zytix Tablet 250 mg work?

It works by blocking the enzyme CYP17A1, which is involved in the production of androgens like testosterone. Reducing androgen levels can slow the growth of prostate cancer cells.

3. What is Zytix Tablet 250 mg used for?

It is primarily used to treat prostate cancer that has spread and is resistant to traditional hormonal treatments.

4. What is the usual dosage of Zytix Tablet 250 mg?

The typical dosage is 1,000 mg once daily, taken on an empty stomach with water, followed by a glucocorticoid such as prednisone or prednisolone.

5. How should I take Zytix Tablet 250 mg?

Swallow the tablet whole, and avoid eating for at least 2 hours before and 1 hour after taking the medication to ensure its proper absorption.

6. Can I take Zytix Tablet 250 mg with food?

No, it should be taken on an empty stomach for better absorption. Avoid food for at least 2 hours before and after taking it.

7. What should I do if I miss a dose of Zytix Tablet 250 mg?

If you miss a dose, take it as soon as you remember, unless it's almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule.

8. What are the common side effects of Zytix Tablet 250 mg?

  • Fatigue
  • Joint pain
  • Hot flashes
  • Diarrhea
  • Low potassium levels (hypokalemia)

9. Can Zytix Tablet 250 mg cause high blood pressure?

Yes, Abiraterone can cause high blood pressure (hypertension) as a side effect.

10. Can I take Zytix Tablet 250 mg if I have liver problems?

If you have liver problems, your doctor may need to adjust the dosage or monitor your liver function more closely while taking Abiraterone.

11. Is Zytix Tablet 250 mg safe during pregnancy?

No, it is not safe for use during pregnancy and should not be used by pregnant women as it can harm the fetus.

12. Is Zytix Tablet 250 mg safe while breastfeeding?

No, it is not recommended to take Abiraterone while breastfeeding as it can pass into breast milk.

13. Can I drive while taking Zytix Tablet 250 mg?

Abiraterone can cause dizziness and fatigue, so you should avoid driving if you feel these side effects.

14. Can Zytix Tablet 250 mg interact with other medications?

Yes, it can interact with medications like blood thinners, corticosteroids, and certain antifungals, so inform your doctor about all medications you are taking.

15. Can Zytix Tablet 250 mg cause weight gain?

Yes, some individuals may experience weight gain as a side effect of Abiraterone.

16. How does Zytix Tablet 250 mg affect testosterone levels?

Abiraterone lowers testosterone levels, which helps in controlling prostate cancer growth.

17. Can Zytix Tablet 250 mg be used to treat breast cancer?

No, Abiraterone is specifically used for prostate cancer and is not approved for the treatment of breast cancer.

18. What is the recommended glucocorticoid to take with Abiraterone?

Prednisone or prednisolone is typically prescribed to be taken alongside Abiraterone to reduce side effects related to adrenal insufficiency.

19. How long should I take Zytix Tablet 250 mg?

Abiraterone is usually taken until the prostate cancer becomes resistant to the drug, as determined by your doctor.

20. Can I stop taking Zytix Tablet 250 mg suddenly?

No, you should not stop taking Abiraterone without consulting your doctor. Gradual adjustment may be necessary.

21. Can Zytix Tablet 250 mg cause nausea?

Yes, nausea is a potential side effect, although it is not common.

22. How does Zytix Tablet 250 mg affect bone health?

Abiraterone can cause bone thinning (osteoporosis), so your doctor may monitor your bone health and recommend supplements.

23. Can I take Zytix Tablet 250 mg with a vitamin D supplement?

Yes, but you should inform your doctor if you are taking any vitamin D supplements.

24. Does Zytix Tablet 250 mg lower my immune system?

Yes, it can lower your immune system by affecting adrenal gland function.

25. Can Zytix Tablet 250 mg affect my fertility?

Abiraterone may affect fertility in men, so it is advised to consult a doctor about the potential impact on reproductive health.

26. Can I take Zytix Tablet 250 mg if I have diabetes?

Abiraterone can affect blood sugar levels, so diabetics should monitor their levels carefully while on this medication.

27. Can Zytix Tablet 250 mg cause dizziness?

Yes, dizziness is a possible side effect, especially when standing up quickly.

28. Is Zytix Tablet 250 mg available over the counter?

No, Zytix Tablet 250 mg is a prescription medication and should be taken under a doctor's supervision.

29. How does Zytix Tablet 250 mg compare to other prostate cancer treatments?

Abiraterone is often used when other treatments like chemotherapy or traditional hormonal therapy fail to control prostate cancer.

30. Can Zytix Tablet 250 mg be used for early-stage prostate cancer?

It is typically used for advanced or metastatic prostate cancer, not early-stage prostate cancer.

31. Can I take Zytix Tablet 250 mg if I have heart disease?

If you have heart disease, consult your doctor before taking Abiraterone, as it can cause high blood pressure and affect your heart.

32. Can Zytix Tablet 250 mg be taken with antihypertensive medications?

Yes, but it is important to monitor your blood pressure regularly, as Abiraterone can cause hypertension.

33. What should I do if I experience severe side effects?

If you experience severe side effects, such as chest pain, difficulty breathing, or severe fatigue, seek immediate medical attention.

34. Can Zytix Tablet 250 mg cause kidney problems?

Abiraterone may affect kidney function, so kidney function should be monitored during treatment.

35. What are the long-term effects of taking Zytix Tablet 250 mg?

Long-term use may lead to side effects like osteoporosis, liver issues, and adrenal insufficiency, which require ongoing monitoring.

36. Can Zytix Tablet 250 mg affect my skin?

Yes, skin rashes or changes in skin texture can sometimes occur with Abiraterone use.

37. Can I drink alcohol while taking Zytix Tablet 250 mg?

It's best to avoid alcohol as it may exacerbate side effects like dizziness and liver strain.

38. Can Zytix Tablet 250 mg be used after chemotherapy?

Yes, Abiraterone is commonly used after chemotherapy to manage advanced prostate cancer.

39. Does Zytix Tablet 250 mg require regular blood tests?

Yes, regular blood tests are necessary to monitor liver function, blood pressure, and potassium levels.

40. Can Zytix Tablet 250 mg cause depression?

Yes, some users may experience mood changes, including depression.

41. Can Zytix Tablet 250 mg be used for other types of cancer?

It is specifically approved for prostate cancer and is not used for other types of cancer.

42. Can Zytix Tablet 250 mg cause fatigue?

Yes, fatigue is one of the more common side effects.

43. How do I know if Zytix Tablet 250 mg is working?

Your doctor will monitor your PSA (prostate-specific antigen) levels and other signs to determine if the medication is effective.

44. Can Zytix Tablet 250 mg be taken with aspirin?

Consult your doctor, as aspirin can affect blood clotting and interact with certain cancer treatments.

45. Can I take Zytix Tablet 250 mg for pain management?

Abiraterone is not used for pain management, but it helps control the growth of cancer cells.

46. What should I do if I accidentally overdose on Zytix Tablet 250 mg?

Seek immediate medical attention if you suspect an overdose.

47. Can Zytix Tablet 250 mg cause hair loss?

Hair loss is not a common side effect but may occur in some patients.

48. Can Zytix Tablet 250 mg cause digestive problems?

Yes, some people experience symptoms like nausea, diarrhea, or constipation.

49. Can I take Zytix Tablet 250 mg with other cancer medications?

Yes, but always consult your oncologist to avoid potential drug interactions.

50. How long will I need to take Zytix Tablet 250 mg?

The duration depends on how well the drug controls your cancer and your doctor's recommendation.

Medical review

Last reviewed: 24 Jul 2026

Medically reviewed by:

This is general information, not personal medical advice. Consult a doctor before taking any medicine.

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