Zopilone Tablet 1 mg Introduction
Zopilone Tablet 1 mg (brand name Lunesta) is a nonbenzodiazepine hypnotic agent that is typically used to treat insomnia. It works to induce sleep by affecting certain brain chemicals in the body that are related to sleep. Zopilone Tablet 1 mg is only intended for short-term use, as it can cause tolerance and dependence.
Uses For Zopilone Tablet 1 mg
Zopilone Tablet 1 mg is commonly prescribed for the treatment of insomnia. Common symptoms of insomnia include difficulty falling asleep, frequently waking up during the night, and not feeling well-rested upon waking up. Zopilone Tablet 1 mg can help to mitigate these symptoms by helping to induce sleep faster and staying asleep longer.
| Brand Name | Zopilone |
|---|---|
| Type | Tablet |
| Weight | 1 mg |
| Generic | Eszopiclone |
| Manufacturer | Incepta Pharmaceuticals Ltd. |
| Available in | English বাংলা |
Mechanism of Action
Zopilone Tablet 1 mg works by binding to GABA-A receptors in the brain and is believed to interact with the neurotransmitter gamma-aminobutyric acid (GABA). This binding to the GABA-A receptors helps to reduce the amount of neuronal activity in the brain and as a result can induce sleep.
How Long Does It Take to Work?
Zopilone Tablet 1 mg typically begins to work within 30-60 minutes after ingesting the medication.
Absorption
Zopilone Tablet 1 mg is rapidly and completely absorbed into the bloodstream. Peak levels are reached within an hour to an hour and a half after taking the medication.
Route of Elimination
Zopilone Tablet 1 mg is eliminated primarily via the kidneys and also in small amounts through the feces through bile acid conjugation.
Dosage
Adult dose: The dose of Eszopiclone should be individualized. The recommended oral starting dose for most non-elderly adults (ages 18 to 64) is 2 mg immediately before bedtime. Dosing can be initiated at or increased to 3 mg as clinically indicated. The recommended oral starting dose for elderly patients ( ages 65 and older) who have difficulty falling asleep is 1 mg immediately before bedtime. In these patients, the dose may be increased to 2 mg as clinically indicated. For elderly patients who have difficulty staying asleep, the recommended dose is 2 mg immediately before bedtime.Pediatric dose: Pediatric dosing is not available.
Taking Eszopiclone with or immediately after a heavy, high-fat meal results in slower absorption and would be expected to reduce the effect of Eszopiclone on sleep latency.
Zopilone Tablet 1 mg is available as a tablet to be taken orally and comes in dosages of 1 mg, 2 mg, and 3 mg. The recommended starting dose is 2 mg and should not exceed more than 3 mg in a single dose. Lower doses are recommended for elderly patients or those with liver impairment.
Administration
Zopilone Tablet 1 mg should be taken at bedtime as it can cause drowsiness. The medication should not be taken if activities requiring alertness such as driving, or operating machinery are required.
Side Effect
Common side effects associated with Zopilone Tablet 1 mg include drowsiness, dizziness, lightheadedness, headache, diarrhea, dry mouth, and unusual dreams.
Toxicity
Zopilone Tablet 1 mg has a low toxicity profile and the most common side effects are usually minor. Overdose symptoms can include confusion, slow breathing, and loss of consciousness.
Precaution
Zopilone Tablet 1 mg can cause drowsiness and it is important to use caution when taking the medication if engaging in activities that require alertness, such as driving. Patients should also avoid alcohol while taking Zopilone Tablet 1 mg as this may increase the side effects.
Interaction
Zopilone Tablet 1 mg may interact with a number of medications, including sedatives, benzodiazepines, antifungals, birth control pills, and certain antibiotics. Patients should inform their doctor of any other medications they are taking prior to taking Zopilone Tablet 1 mg.
Disease Interaction
Zopilone Tablet 1 mg may interact with a number of diseases whereby the symptoms of the disease may be worsened when taking the medication. Diseases such as COPD, depression, kidney disease, liver disease, as well as certain mental health disorders should be discussed with the doctor prior to taking the medication.
Drug Interaction
Zopilone Tablet 1 mg may interact with certain drugs and may increase the effects of other medications, such as opioids, benzodiazepines, and various other central nervous system depressants. Patients should inform their doctor of any drugs they are taking prior to taking Zopilone Tablet 1 mg.
Food Interactions
Zopilone Tablet 1 mg may interact with certain foods and patients should avoid taking it with grapefruit or grapefruit juice.
Pregnancy Use
Zopilone Tablet 1 mg is contraindicated during pregnancy, as it can cause significant harm to the fetus. Therefore, women who are pregnant or planning to become pregnant should avoid taking Zopilone Tablet 1 mg.
Lactation Use
Zopilone Tablet 1 mg is not recommended for use during breastfeeding due to the potential risk to the infant.
Acute Overdose
Acute overdose of Zopilone Tablet 1 mg can be life threatening and patients should seek immediate medical attention if an overdose is suspected. Symptoms of an overdose may include confusion, coma, slurred speech, and loss of consciousness.
Contraindication
Zopilone Tablet 1 mg is contraindicated for anyone with a known hypersensitivity to the drug. It is also not recommended for anyone with severe respiratory depression or a history of substance abuse. Patients with renal or hepatic impairment should exercise caution when taking the drug.
Use Direction
Zopilone Tablet 1 mg should be taken as directed by the patient's doctor and should be taken at bedtime. The tablet should be swallowed whole and not broken or dissolved. The dosage for the medication should also be discussed with the doctor prior to taking the medication.
Storage Condition
Zopilone Tablet 1 mg should be stored at room temperature in a dry place. It should also be kept out of the reach of children and pets.
Volume of Distribution
Zopilone Tablet 1 mg has a volume of distribution of about 0.3 L/kg.
Half Life
Zopilone Tablet 1 mg has an elimination half-life of 6-12 hours in healthy adults.
Clearance
Zopilone Tablet 1 mg has a renal clearance of 0.3 L/h/kg.
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