Zinc sulfate monohydrate, also known as zinc sulfate heptahydrate, is an inorganic salt used as a dietary supplement to treat zinc deficiency. It is an odorless, colorless, crystalline powder that is water soluble and easily absorbed in the intestine.
Uses
Zinc sulfate monohydrate is used to treat zinc deficiency, which may manifest in inadequate growth, poor taste sensation, and dermatological disorders. It can also be used to reduce age-related eye disease, as a skin disinfectant, and as a supplement for people with marginal zinc intake. Furthermore, zinc sulfate monohydrate is a common health supplement for people on low-calorie diets•
Zinc is an essential micronutrient required for various biochemical processes in the body, and zinc sulfate is one of the most easily absorbed forms. It is absorbed primarily in the jejunum of the small intestine and provides essential zinc for many hormones and enzymes necessary for proper functioning of the body.
How Long Does It Take to Work?
When taken in supplement form as part of a balanced diet, zinc sulfate monohydrate can work within a few weeks to six months, depending on the individual's overall zinc status and the severity of the deficiency.
Absorption
Zinc sulfate monohydrate is easily absorbed in the intestine due to its high solubility in water.
Route of Elimination
Zinc sulfate monohydrate is eliminated mostly in the feces through gastrointestinal absorption. Small amounts may be lost in the urine.
Dosage
Child under 10 kg: 5 ml (1 teaspoonful) 2 times daily after food. Child between 10-30 kg: 10 ml (2 teaspoonfuls) 1-3 times daily after food. Adults and child over 30 kg: 20 ml (4 teaspoonfuls) 1-3 times daily after food.
This drug is most effective if they are taken at least 1 hour before or 2 hour after meals. However, if causes stomach upset, this may be taken with a meal.
The recommended dosage of zinc sulfate monohydrate varies from 3-24mg daily, depending on age and sex. For adults and children over the age of 4, the recommended daily allowance (RDA) is 11mg daily. For infants and children under 4 years, the RDA ranges from 3-9mg. For pregnant women, an additional 2mg of zinc sulfate monohydrate is recommended.
Administration
Zinc sulfate monohydrate can be taken orally, either alone or in combination with other vitamins and minerals. It can also be applied to the skin as an ointment or cream.
Side Effect
Common side effects of zinc sulfate monohydrate include nausea, vomiting, abdominal cramps, and diarrhea. It can also lead to increased red blood cell production and a decrease in copper levels. High doses can result in liver and kidney toxicity.
Toxicity
Zinc is required in only small amounts, and high doses are toxic. Toxicity symptoms usually become noticeable at doses of over 320mg/day. Symptoms of zinc toxicity include nausea, vomiting, abdominal pain, weakness, and difficulty breathing.
Precautions
Zinc sulfate monohydrate should be taken with caution in people with renal dysfunction, liver disease, diabetes, and peptic ulcer. Long-term use should be monitored by a healthcare professional.
Interactions
Zinc sulfate monohydrate may interact with certain medications, including tetracycline antibiotics, penicillamine, erythromycin, and cisplatin.
Disease Interactions
Zinc sulfate monohydrate may interact with certain diseases, such as high blood pressure, renal dysfunction, and peptic ulcer.
Drug Interactions
Zinc sulfate monohydrate may interact with certain drugs, including tetracycline antibiotics, penicillamine, erythromycin, and cisplatin.
Food Interactions
Zinc sulfate monohydrate may interact with some foods, such as milk, eggs, and zinc-rich foods.
Pregnancy Use
Pregnant women should take zinc sulfate monohydrate with caution, as there is not enough research to determine its safety.
Lactation Use
There is not enough data to recommend zinc sulfate monohydrate for lactating women. Speak to your healthcare provider before taking any zinc supplement.
Acute Overdose
Signs and symptoms of an acute overdose include nausea, vomiting, and abdominal pain. It is recommended to contact a healthcare professional immediately if an overdose is suspected.
Contraindication
Zinc sulfate monohydrate should be avoided in people with hypersensitivity to zinc or any component of the medication.
Use Direction
Zinc sulfate monohydrate should be taken as directed by your healthcare provider, usually one to three times daily.
Storage Condition
Zinc sulfate monohydrate should be stored at room temperature in a tightly sealed container, away from moisture, heat, and light.
Volume of Distribution
The volume of distribution of zinc sulfate monohydrate is 4.9-5.2L/kg.
Half-Life
The half-life of zinc sulfate monohydrate is between 32-37 hours.
Clearance
The clearance of zinc sulfate monohydrate is approximately 1.22-1.5ml/min/kg.