Versil Tablet

Introduction

Perindopril arginine is a long-acting, blunt-acting angiotensin-converting-enzyme (ACE) inhibitor with antihypertensive properties. It is used for the treatment and prevention of heart failure, hypertension (high blood pressure), and post-myocardial infarction (heart attack). Its active metabolite perindoprilat is thought to act by blocking the angiotensin-converting-enzyme, resulting in a decrease in blood pressure.

Uses For

Perindopril arginine is used primarily for the treatment and prevention of heart failure, hypertension, and post-myocardial infarction.

Brand Name	Versil
Type	Tablet
Weight	4 mg
Generic	Perindopril Arginine
Manufacturer	ACME Laboratories Ltd.
Available in	English বাংলা

Mechanism of Action

Perindopril arginine is a long-acting, blunt-acting angiotensin-converting-enzyme (ACE) inhibitor, blocking the angiotensin-converting-enzyme (ACE). This action causes an increase in bradykinin and prostaglandin levels, resulting in a decrease in blood pressure.

How Long Does it Take to Work?

Perindopril arginine may take several weeks to become fully effective, and the full effect may not be seen until 6-8 weeks after starting the drug. The drug should be used as directed by your doctor for optimal results.

Absorption

Perindopril arginine is rapidly absorbed following oral administration, with peak plasma levels within 1-4 hours. The bioavailability of perindopril is low (<25%) and is decreased with food.

Route of Elimination

Perindopril arginine is metabolized primarily via the liver into its active metabolite, perindoprilat, which is then excreted renally.

Dosage

Hypertension: One Perindopril 4 tablet once daily preferably in the morning. If necessary, the dose may be increased to 8 mg after 1 month of treatment. Perindopril should be taken before food.

Stable coronary artery disease: Perindopril 4 once daily for two weeks, then increased to 8 mg once daily, depending on renal function and provided that the 4 mg dose is well tolerated. Elderly patients should receive Perindopril 2 mg once daily for one week, then Perindopril 4 once daily the next week, before increasing the dose up to 8 mg once daily, depending on renal, function. The dose should be increased only if the previous lower dose is well tolerated.

Congestive heart failure: Perindopril should be started under close medical supervision at a starting dose of 2 mg in the morning. If necessary dose may be increased to 4 mg.

Elderly patients: Start at low daily dose (4 mg or less) and titrate slowly as needed. Experience with doses exceeding 8 mg is limited.

The usual starting dose of Perindopril arginine is 2-4 mg daily, either as a single dose or divided into two doses. The recommended dose for the treatment of hypertension is 4-8 mg daily; the recommended dose for the treatment of high cholesterol is 8-32 mg daily. Higher doses may be necessary in some patients for adequate control of blood pressure.

Administration

Perindopril arginine should be taken orally with or without food. It is best to take the medication at the same time each day. If a dose is missed, take it as soon as possible and then continue taking it at the regular scheduled time.

Side Effects

The most common side effects of Perindopril arginine include dizziness, fatigue, headache, and cough. Other possible side effects include nausea, vomiting, diarrhea, abdominal pain, confusion, and weakness. These side effects may go away with continued use of the drug.

Toxicity

Perindopril arginine has a low toxicity. The drug is generally well-tolerated, but an overdose of the drug can cause serious, life-threatening side effects such as hypotension, bradycardia, arrhythmias, and shock.

Precautions

Before taking Perindopril arginine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This drug may contain inactive ingredients, which can cause allergic reactions or other problems. It is important to tell your doctor about any and all medications you are taking, including over-the-counter drugs, vitamins, and herbal supplements. Be sure to tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Interactions

Perindopril arginine can interact with other medications that may affect blood pressure, including diuretics, beta-blockers, and angiotensin-converting-enzyme inhibitors, so it is important to tell your doctor about all medications and supplements you are taking. It can also interact with drugs metabolized by CYP450 enzymes, such as certain antifungal medicines.

Disease Interaction

Perindopril arginine can worsen certain heart and kidney diseases, asthma, and diabetes and can interact with certain blood pressure medications. Consult your doctor for guidance if you have a pre existing condition.

Drug Interaction

Perindopril arginine can interact with other medications, including certain antifungal medications, and drugs metabolized by CYP450 enzymes. It is important to tell your doctor about all medications and supplements you are taking, including over-the-counter drugs, vitamins, and herbal supplements.

Food Interactions

Perindopril arginine should be taken with food or a light meal. It should not be taken with grapefruit or grapefruit juice.

Pregnancy Use

Perindopril arginine should not be used during pregnancy unless advised by your doctor. It may cause birth defects or fetal death if used in the third trimester of pregnancy.

Lactation Use

Perindopril arginine should not be used while breastfeeding, as it can pass into breast milk.

Acute Overdose

An overdose of Perindopril arginine can cause serious, life-threatening side effects, including hypotension, bradycardia, arrhythmias, and shock. Seek immediate medical attention if an overdose is suspected.

Contraindication

Perindopril arginine is contraindicated in patients with a history of angioedema, hyperkalemia, and in patients with kidney and liver impairment.

Use Direction

Perindopril arginine should be taken orally, with or without food, as prescribed by your doctor. The medication should be taken at the same time each day for optimal results.