About Trusert HZ Tablet 80 mg+12.5 mg
Trusert HZ Tablet 80 mg+12.5 mg is a brand medicine
manufactured by Ziska Pharmaceuticals Ltd. containing the generic Telmisartan + Hydrochlorothiazide
(80 mg+12.5 mg).
Current listed price in Bangladesh: Unit: ৳ 18.00 (3 x 10: ৳ 540.00) Strip: ৳ 180.00.
Medical information for Trusert HZ Tablet 80 mg+12.5 mg
Uses, dosage, side effects, and safety details below apply to
Trusert HZ Tablet 80 mg+12.5 mg
(generic:
Telmisartan + Hydrochlorothiazide).
This is general information — consult a doctor before use.
Introduction
Trusert HZ Tablet 80 mg+12.5 mg is a combination drug containing telmisartan, a selective angiotensin II receptor antagonist, and hydrochlorothiazide, a thiazide diuretic. It is used to treat hypertension (high blood pressure).
Uses for
Trusert HZ Tablet 80 mg+12.5 mg is prescribed to treat hypertension (high blood pressure) in adults and adolescents (12 years and older). It may in some cases be used to treat heart failure or kidney failure related to hypertension. In addition, it may be used to reduce the risk of stroke or heart attack in patients at risk for these complications.
Mechanism of Action
Telmisartan works by blocking the action of angiotensin II, a hormone which narrows blood vessels and increases blood pressure. Hydrochlorothiazide, a thiazide diuretic, works by increasing the amount of salt and water removed from the body, helping to lower blood pressure.
How long does it take to work?
It can take several weeks of regular use for Trusert HZ Tablet 80 mg+12.5 mg to reach its full effect on blood pressure. However, some people may notice an improvement sooner, typically within 1–2 weeks.
Absorption
Once taken, Trusert HZ Tablet 80 mg+12.5 mg is quickly absorbed in the body, with peak concentration reached within 1-3 hours.
Route of Elimination
After being absorbed in the body, Trusert HZ Tablet 80 mg+12.5 mg is eliminated primarily through the kidneys.
Dosage
The recommended starting dose of Trusert HZ Tablet 80 mg+12.5 mg in adults and adolescents (12 years and older) with hypertension is 40 mg/12.5 mg once daily. Depending on blood pressure response, the dose may be increased to 80 mg once daily, if necessary. The maximum dose is 80 mg/25 mg per day.
Administration
Trusert HZ Tablet 80 mg+12.5 mg should be taken orally with or without food, once daily.
Side Effect
Common side effects of Trusert HZ Tablet 80 mg+12.5 mg includes dizziness, headache, stuffy or runny nose, nausea, abdominal pain, sore throat, cough, fatigue, impotence in men, and menstrual irregularities in women.
Toxicity
Trusert HZ Tablet 80 mg+12.5 mg has been found to be safe when taken as prescribed. On rare occasions, overdose of Trusert HZ Tablet 80 mg+12.5 mg can lead to severe hypotension (low blood pressure), orthostatic hypotension (fall in blood pressure when changing posture from sitting to standing), or electrolyte imbalance.
Precaution
Trusert HZ Tablet 80 mg+12.5 mg must not be administered during pregnancy, since it can cause harm to the developing fetus. Patients should notify their doctor if they become pregnant while taking the drug. The drug should also be used cautiously in patients with liver disease, kidney disease, diabetes, and in elderly patients.
Interaction
Trusert HZ Tablet 80 mg+12.5 mg may interact with other drugs, including nonsteroidal anti-inflammatory drugs (NSAIDs), warfarin, lithium, ibuprofen, and aspirin.
Disease Interaction
Trusert HZ Tablet 80 mg+12.5 mg may worsen conditions associated with kidney failure, such as high potassium levels, low blood pressure, and lupus.
Drug Interaction
Drugs that can interact with Trusert HZ Tablet 80 mg+12.5 mg include nonsteroidal anti-inflammatory drugs (NSAIDs), warfarin, lithium, ibuprofen, and aspirin.
Food Interactions
No food interactions have been reported with Trusert HZ Tablet 80 mg+12.5 mg.
Pregnancy Use
Trusert HZ Tablet 80 mg+12.5 mg must not be administered during pregnancy, as it can cause harm to the developing fetus. Patients should notify their doctor if they become pregnant while taking the drug.
Lactation Use
It is not known whether Trusert HZ Tablet 80 mg+12.5 mg passes into breast milk. It should be avoided while breastfeeding, as it may cause harm to the nursing infant.
Acute Overdose
Acute overdose of Trusert HZ Tablet 80 mg+12.5 mg can lead to severe hypotension (low blood pressure), orthostatic hypotension (fall in blood pressure when changing posture from sitting to standing), or electrolyte imbalance.
Contraindication
Trusert HZ Tablet 80 mg+12.5 mg should not be used in patients with allergy or hypersensitivity to any of its components, or in patients with severe renal impairment.
Use direction
Trusert HZ Tablet 80 mg+12.5 mg should be taken orally with or without food, once daily.
Storage condition
Trusert HZ Tablet 80 mg+12.5 mg should be stored at room temperature (59–86°F/ 15–30°C).
Volume of Distribution
Trusert HZ Tablet 80 mg+12.5 mg is widely distributed throughout the body, with a volume of distribution of about 4.3 L/kg.
Half Life
The elimination half-life of Trusert HZ Tablet 80 mg+12.5 mg is about 11–14 hours.
Clearance
The total clearance of Trusert HZ Tablet 80 mg+12.5 mg is approximately 0.3 L/hr/kg.
Full generic monograph:
Telmisartan + Hydrochlorothiazide — uses, dosage & side effects
Medical review
Last reviewed:
30 Aug 2024
Medically reviewed by:
This is general information, not personal medical advice. Consult a doctor before taking any medicine.
See detailed version on Trusert HZ Tablet 80 mg+12.5 mg and Trusert HZ Tablet 80 mg+12.5 mg in Bangla.
Taking medicines without doctor's advice can cause long-term problems.
