Telisa Tablet

Introduction

Telisa Tablet 40 mg is a medication that belongs to the angiotensin-II receptor blocker (ARB) class. It is used to treat high blood pressure (hypertension), heart failure, and other related disorders.

Uses

Telisa Tablet 40 mg is used to treat hypertension and heart failure. It is also indicated for the prevention of cardiovascular morbidity in high-risk patients, and for reducing the risk of stroke and other major cardiovascular events. It can also be used to prevent kidney damage in diabetic patients.

Brand Name	Telisa
Type	Tablet
Weight	40 mg
Generic	Telmisartan
Manufacturer	ACME Laboratories Ltd.
Available in	English বাংলা

Mechanism of Action

Telisa Tablet 40 mg works by blocking the actions of angiotensin-II (a protein that causes blood vessels to constrict) and thereby widening the blood vessels so that the pressure of the blood is reduced.

How Long Does it Take to Work?

Generally, the effects of telmisartan can be seen within 2 weeks of starting the medication. However, it may take up to 4 weeks of regular use for the effects of the medication to become fully evident.

Absorption

Telisa Tablet 40 mg is well absorbed from the gastrointestinal tract with peak plasma concentrations being achieved in 3-4 hours after an oral dose.

Route of Elimination

The majority of the telmisartan is eliminated unchanged in the urine, via active tubular secretion.

Dosage

Dosage must be individualized. The usual starting dose of Telmisartan tablets is 40 mg once a day. Blood pressure response is dose-related over the range of 20 to 80 mg. Most of the antihypertensive effect is apparent within 2 weeks and maximal reduction is generally attained after 4 weeks. When additional blood pressure reduction beyond that achieved with 80 mg Telmisartan is required, may switch to the combination. No initial dosage adjustment is necessary for elderly patients or patients with renal impairment, including those on hemodialysis. Patients on dialysis may develop orthostatic hypotension; their blood pressure should be closely monitored. Telmisartan tablets may be administered with other antihypertensive agents. Telmisartan tablets may be administered with or without food. Initial therapy with Telmisartan is not recommended in patients ≥75 years old or with hepatic impairment.

Pediatric use: The safety and effectiveness of Telmisartan in pediatric patients have not been established.

Geriatric use: No overall differences in effectiveness and safety were observed in these patients compared to younger patients.

Hepatic impairment: Monitor carefully and up titrate slowly in patients with biliary obstructive disorders or hepatic insufficiency. The recommended dose of telmisartan is 20-80 mg orally once per day. The dose should be adjusted based on the patient's response and should not exceed 80 mg once daily.

Administration

Telisa Tablet 40 mg should be taken orally with food or a glass of water, once daily. It is not recommended to crush, chew or split the tablets.

Side Effects

Common side effects of telmisartan include dizziness, headache, fatigue, diarrhea, stomach pain, and increased urination. Less common but serious side effects include liver damage, fainting, and elevated blood sugar levels.

Toxicity

Telisa Tablet 40 mg is relatively safe and well-tolerated. Overdose of telmisartan may cause hypotension (low blood pressure), hyperkalemia (high potassium levels in the blood), and bradycardia (slow heart rate).

Precaution

Patients should inform their doctor about any medical history, the use of any other prescription or over-the-counter medications, as well as supplements and vitamins prior to taking telmisartan. Telisa Tablet 40 mg should be used with caution in pregnant or breastfeeding women.

Interaction

Telisa Tablet 40 mg may interact with other medications such as potassium-sparing diuretics, potassium supplements, angiotensin-converting enzyme (ACE) inhibitors (such as lisinopril, enalapril), and nonsteroidal anti-inflammatory drugs (NSAIDs).

Disease Interaction

Patients with diabetes, hypertension, congestive heart failure, liver disease, or kidney disease should use telmisartan with caution and be monitored more closely by a doctor.

Drug Interaction

Use of telmisartan with certain drugs, including angiotensin-converting enzyme (ACE) inhibitors (such as lisinopril, enalapril), diuretics, nonsteroidal anti-inflammatory drugs (NSAIDs), and potassium-sparing agents may increase the risk of adverse effects.

Food Interactions

Telisa Tablet 40 mg should be taken with food for optimal absorption.

Pregnancy Use

Telisa Tablet 40 mg should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Lactation Use

Telisa Tablet 40 mg is not recommended for use in breastfeeding mothers as it is excreted in breast milk and may cause adverse reactions in the infant.

Acute Overdose

If an overdose of telmisartan is suspected, the patient should be monitored for symptoms of hypotension and hypovolemia (low blood volume). Treatment of overdose involves supportive care, which may include intravenous fluids, sympatomimetic agents (such as epinephrine), and diuretics.

Contraindication

Telisa Tablet 40 mg is contraindicated in patients with hypersensitivity to any of the ingredients of the medication, severe hepatic impairment, and in patients with biliary cirrhosis.

Use Direction

Telisa Tablet 40 mg should be used as directed by the doctor. It is generally recommended to take the dose in the morning to avoid it interfering with sleep.

Storage Condition

Telisa Tablet 40 mg should be stored at room temperature, between 15°C and 30°C. Keep medication away from light, moisture, and heat. Store out of reach of children and pets.