Suprafol TR Capsule (Timed Release)

Introduction

Ferrous fumarate and folic acid are often combined in dietary supplements to address deficiencies in iron and folate. Ferrous fumarate is an iron salt used to treat or prevent iron deficiency anemia, while folic acid is a form of vitamin B9 necessary for the formation of red blood cells and DNA synthesis.

Uses

The combination of ferrous fumarate and folic acid is used to:

Treat and prevent iron deficiency anemia.
Supplement folic acid in individuals with low levels, such as pregnant women or those with dietary deficiencies.
Support overall hematologic health and improve red blood cell production.

Brand Name	Suprafol TR
Type	Capsule (Timed Release)
Weight	200 mg+200 mcg
Generic	Ferrous Fumarate + Folic acid
Manufacturer	Supreme Pharmaceutical Ltd.
Available in	English বাংলা

Mechanism of Action

Ferrous fumarate provides elemental iron, which is essential for the production of hemoglobin and red blood cells. Folic acid is crucial for DNA synthesis and cell division. Together, they help correct iron and folate deficiencies, promoting the production of healthy red blood cells and preventing anemia.

How Long Does It Take to Work?

Improvement in symptoms of anemia, such as fatigue and weakness, can be observed within a few weeks of starting treatment. Full correction of anemia and normalization of blood parameters may take several months, depending on the severity of the deficiency and adherence to the regimen.

Absorption

Ferrous fumarate is absorbed in the gastrointestinal tract, primarily in the duodenum and jejunum. Folic acid is also absorbed in the upper part of the small intestine. Iron absorption can be enhanced by consuming the supplement with vitamin C or on an empty stomach, while folic acid absorption is generally efficient.

Route of Elimination

Ferrous fumarate is eliminated through feces and urine, with a majority of the absorbed iron being incorporated into hemoglobin or stored in the body. Folic acid is also excreted primarily through urine, with excess amounts being rapidly cleared from the body.

Dosage

Adults: One tablet daily. When necessary one tablet may be given twice daily. In pregnancy, it is recommended that Irolic tablet should be started at first antenatal consolation and continues for 3 months after delivery. The tablet should preferably be taken before meals; if there are gastro-intestinal disturbances, doses may be taken after meals.

The dosage varies depending on the severity of deficiency and the formulation:

For iron deficiency anemia: Typically, 100-200 mg of elemental iron per day (from ferrous fumarate) in divided doses.
For folic acid deficiency: Usually 400-800 mcg per day, depending on individual needs and medical advice.
For pregnant women: Often recommended as 27-30 mg of elemental iron and 400-800 mcg of folic acid daily, or as directed by a healthcare provider.

Administration

Ferrous fumarate and folic acid are usually administered orally in tablet or capsule form. It's important to follow the specific dosing instructions provided by a healthcare provider or included in the product labeling.

Side Effects

Common side effects of ferrous fumarate may include:

Gastrointestinal discomfort, such as nausea, constipation, or diarrhea.
Darkened stools.

Common side effects of folic acid are rare but can include:

Allergic reactions.
Unusual taste in the mouth.

Toxicity

Iron toxicity can occur with excessive intake, leading to symptoms such as abdominal pain, vomiting, and diarrhea. Severe cases can cause organ damage. Folic acid toxicity is rare but can potentially mask vitamin B12 deficiency symptoms if taken in excessive amounts.

Precautions

Precautions include:

Monitor for symptoms of iron overload, especially in patients with hemochromatosis or other iron-storage disorders.
Ensure adequate vitamin B12 levels to avoid masking deficiency symptoms with high doses of folic acid.
Take the supplement as directed and avoid exceeding the recommended dosage.

Interaction

Ferrous fumarate may interact with:

Certain antibiotics (e.g., tetracyclines), reducing their effectiveness.
Antacids or calcium supplements, which can inhibit iron absorption.

Folic acid may interact with:

Anti-seizure medications, which may reduce folic acid levels.
Some medications used for rheumatoid arthritis.

Disease Interaction

Use with caution in individuals with:

Gastrointestinal diseases or conditions affecting iron absorption.
Vitamin B12 deficiency, as folic acid supplementation can mask its symptoms.

Drug Interaction

Interactions may occur with:

Iron supplements and certain medications affecting absorption, such as proton pump inhibitors or H2 blockers.
Folic acid and medications that affect folate metabolism or absorption.

Consult a healthcare provider for specific advice on drug interactions.

Food Interactions

Iron absorption can be inhibited by:

Coffee and tea.
Calcium-rich foods.

Folic acid absorption is generally not affected by food, but maintaining a balanced diet supports overall health.

Pregnancy Use

Ferrous fumarate and folic acid are commonly used during pregnancy to prevent or treat anemia and support fetal development. Dosage should be adjusted based on individual needs and medical advice, often with higher doses recommended to meet increased nutritional requirements.

Lactation Use

These supplements are also considered safe during lactation. Adequate iron and folic acid levels are important for both maternal health and the nutritional quality of breast milk.

Acute Overdose

Acute overdose of iron can lead to severe symptoms, including gastrointestinal distress, systemic toxicity, and organ damage. Seek immediate medical attention if an overdose is suspected. Overdose of folic acid is less likely to cause serious harm but should still be monitored.

Contraindication

Ferrous fumarate and folic acid are contraindicated in:

Individuals with known hypersensitivity to these compounds.
Patients with iron overload conditions, such as hemochromatosis or hemosiderosis.

Use Direction

Follow the dosage instructions provided by the healthcare provider or included in the product labeling. Take the supplements with water, and avoid taking them with substances that may inhibit absorption, such as dairy products or antacids.

Storage Conditions

Store at room temperature, away from moisture and direct sunlight. Keep out of reach of children. Follow specific storage instructions provided with the product.

Volume of Distribution

The volume of distribution is not typically specified for ferrous fumarate and folic acid due to their oral administration and localized action in the body.

Half Life

The half-life of ferrous fumarate is not well-defined but is approximately 6-8 hours for iron in the body. Folic acid has a half-life of about 6 hours, but this can vary based on individual metabolism and dosage.

Clearance

Iron and folic acid are primarily cleared through the gastrointestinal tract and urine. Excess iron is stored in the body or eliminated through feces, while folic acid is excreted in urine.

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