Starlix Tablet

Starlix Tablet 120 mg Introduction

Starlix Tablet 120 mg is an antihyperglycemic drug used to control type 2 diabetes. It belongs to the meglitinide class of drugs, and is sometimes used together with insulin or other oral antidiabetic drugs such as metformin. It is most commonly sold under the trade name Starlix.

Uses For Starlix Tablet 120 mg

Starlix Tablet 120 mg is used to treat Type 2 diabetes in combination with diet and exercise. It helps control blood sugar by increasing the level of insulin that the body produces in response to a meal. It is not used in people with Type 1 diabetes.

Mechanism Of Action

Starlix Tablet 120 mg works by stimulating the beta cells of the pancreas to produce insulin. It binds to the ATP-sensitive potassium channels, which activates an enzyme called adenylcyclase. The enzyme transmits a signal to the beta cells, which causes them to release insulin.

How Long Does It Take To Work?

Starlix Tablet 120 mg typically takes about 20 minutes to take effect. It peaks in the bloodstream between 1 and 3 hours after being taken, and its effects are usually fully gone after around 4 hours.

Absorption and Route of Elimination

Starlix Tablet 120 mg is quickly and almost completely absorbed from the gastrointestinal tract, with peak plasma concentrations achieved within 1-3 hours. It is eliminated mainly by the kidneys.

Dosage

The dosage of nateglinide is typically 120 mg three times a day before meals. This can be increased to a maximum of 120 mg up to three times a day before meals. It should be taken 30 minutes before meals and with food.

Administration

Starlix Tablet 120 mg can be taken with or without food. Swallow the tablets whole with a full glass of water. Do not crush, chew, or break the tablets, as this may reduce the effectiveness of the medication.

Side Effects

Common side effects of nateglinide include dizziness, headache, nausea, and upper respiratory tract infection. Severe side effects may include allergic reactions, low white blood cell counts, and lactic acidosis.

Toxicity

The recommended dose of nateglinide is 120 mg three times daily. In clinical trials, a single dose up to 360 mg appeared to be safe. Higher doses may cause toxic effects, including lactic acidosis, hypoglycemia, and low white blood cell counts.

Precautions

Patients should not take nateglinide if they have cirrhosis, liver disease, kidney disease, or a history of lactic acidosis. Patients with type 2 diabetes should use nateglinide with caution as it may worsen their condition. Starlix Tablet 120 mg should also not be taken with insulin or other oral hypoglycemic agents.

Interaction

Drugs that may interact with nateglinide include nonsteroidal anti-inflammatory drugs (NSAIDs), cimetidine, furosemide, and metformin. Patients should also be aware that alcohol may increase the risk of low blood sugar when taking nateglinide.

Disease Interaction

Patients with type 2 diabetes should use nateglinide with caution, as it may worsen their condition. Starlix Tablet 120 mg is also not recommended for patients with cirrhosis, liver disease, and kidney disease. Patients with a history of lactic acidosis should avoid taking nateglinide.

Drug Interaction

Starlix Tablet 120 mg should not be taken with insulin or other oral hypoglycemic agents. Drugs that may interact with nateglinide include nonsteroidal anti-inflammatory drugs (NSAIDs), cimetidine, furosemide, and metformin.

Food Interactions

Starlix Tablet 120 mg should not be taken with food that contain high amounts of fat or sugar, as this may decrease the effect of the medication. Alcohol should also be avoided while taking nateglinide, as this may increase the risk of low blood sugar.

Pregnancy Use

Starlix Tablet 120 mg has not been studied in pregnant women and should be used only if the potential benefit justifies the potential risk to the fetus.

Lactation Use

Starlix Tablet 120 mg has not been studied in nursing mothers and is not recommended for use.

Acute Overdose

Overdose of nateglinide may cause hypoglycemia, lactic acidosis, and decreased white blood cell counts. Treatment of acute overdose includes symptomatic treatment and supportive measures as appropriate.

Contraindication

Starlix Tablet 120 mg is contraindicated in patients who are hypersensitive to it, in patients with type 1 diabetes, and in patients with cirrhosis, liver disease, and kidney disease.

Use Direction

Starlix Tablet 120 mg should be taken at least 30 minutes before meals and with food. The dosage should not exceed 120 mg up to three times a day.

Storage Condition

Starlix Tablet 120 mg should be stored at room temperature, in a dry place, and away from direct heat and light.

Volume of Distribution

The volume of distribution of nateglinide is 125 L.

Half Life

The half-life of nateglinide is around 1-2 hours.

Clearance

The clearance of nateglinide is 0.47 L/h.kg.

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