Introduction
Simet Pediatric Drop 67 mg/ml is a silicon based surfactant that decreases the surface tension of gastrointestinal gas bubbles to facilitate their elimination. It has a favourable safety profile as it is not systemically absorbed.
Uses
Simet Pediatric Drop 67 mg/ml is an anti-flatulence agent used to relieve pressure, bloating, and symptoms referred to as gas.
Simet Pediatric Drop 67 mg/ml is indicated for the treatment of bloating, pressure, and cramps caused by gas. Simet Pediatric Drop 67 mg/ml is also used as part of bowel preparation for colonoscopies.
Associated Conditions
Pharmacodynamics
Simet Pediatric Drop 67 mg/ml decreases the surface tension of gas bubbles in the gastrointestinal tract, facilitating their expulsion. It has a short duration of action as it is generally given as needed, and a wide therapeutic index as it is not systemically absorbed.
Mechanism of Action
Simet Pediatric Drop 67 mg/ml is a surfactant that decreases the surface tension of gas bubbles in the gastrointestinal tract, more easily allowing gas to exit the body.
Absorption
Simet Pediatric Drop 67 mg/ml is not systemically absorbed and so these data are not readily available.
Volume of Distribution
Simet Pediatric Drop 67 mg/ml is not systemically absorbed and so these data are not readily available.
Protein Binding
Simet Pediatric Drop 67 mg/ml is not systemically absorbed and so these data are not readily available.
Route of Elimination
Simet Pediatric Drop 67 mg/ml is eliminated in the feces.
Half Life
Simet Pediatric Drop 67 mg/ml is not systemically absorbed and so these data are not readily available.
Clearance
Simet Pediatric Drop 67 mg/ml is not systemically absorbed and so these data are not readily available.
Toxicity
Data regarding overdoses with simethicone are rare due to the fact that it is not systemically absorbed.. In the case of an overdose stop the drug and initiate symptomatic and supportive care.
Food Interactions
- Take with or without food. Recommendations vary from product to product - consult individual product monographs for additional information.
Dosage
Children less than 2 years of age: 20 mg (0.3 ml Simet Pediatric Drop 67 mg/ml Paediatric Drops) 4 times daily up to 240 mg/day (3.6 ml Simet Pediatric Drop 67 mg/ml Paediatric Drops).
Children 2-12 years of age: 40 mg (0.6 ml Simet Pediatric Drop 67 mg/ml Paediatric Drops) 4 times daily.
Adults:
- 40-125 mg (0.6 ml-1.9 ml Simet Pediatric Drop 67 mg/ml Paediatric Drops) 4 times daily, up to 500 mg/day (7.5 ml Simet Pediatric Drop 67 mg/ml Paediatric Drops) or
- 1-3 Simet Pediatric Drop 67 mg/ml chewable tablets; 4 times daily, up to 500 mg/day (12 Simet Pediatric Drop 67 mg/ml chewable tablets).
