Santinal MR Capsule (Modified Release)

Introduction

Santinal MR Capsule (Modified Release) 200 mg is an antiplatelet drug, commonly used to prevent blood clot development in high-risk patients and is also used to treat conditions such as heart attack, stroke, angina, and deep vein thrombosis.

Uses for

Santinal MR Capsule (Modified Release) 200 mg is commonly used to reduce the risk of blood clots that may occur after surgery, or during and after a variety of heart conditions. Santinal MR Capsule (Modified Release) 200 mg may also be used to lower the risk of stroke and other blood clots in people with certain heart conditions. It is also used to improve the circulation of blood in certain parts of the body.

Brand Name	Santinal MR
Type	Capsule (Modified Release)
Weight	200 mg
Generic	Dipyridamole
Manufacturer	UniMed UniHealth
Available in	English বাংলা

Mechanism of Action

Santinal MR Capsule (Modified Release) 200 mg prevents platelet aggregation, which is a major factor in the pathogenesis of thrombosis. It works by inhibiting activity of the enzyme cyclic adenosine monophosphate (cAMP) and increasing intracellular calcium. It also modifies release of endogenous substances, such as serotonin and thromboxane, that have platelet-activating properties.

How Long Does it Take To Work

The effect of taking dipyridamole usually begins within two to four hours and may take up to 24 hours to reach peak effect. It is important to take this medication as prescribed by your doctor.

Absorption

Santinal MR Capsule (Modified Release) 200 mg is well absorbed after oral administration and undergoes rapid and extensive hepatic metabolism. Peak concentrations of the drug occur within 2-4 hours of administration.

Route of Elimination

Santinal MR Capsule (Modified Release) 200 mg is eliminated mainly by the kidneys, with about <80% of the dose being recovered in the urine and primarily as metabolites.

Dosage

Santinal MR Capsule (Modified Release) 200 mg is available in tablets ranging from 2.5 to 25mg. The typical starting dose for adults is 200mg per day in divided doses, with increases to as much as 400mg daily if needed. For children, the usual starting dose is 2.5mg to 5mg per day, given in divided doses. Dosage and duration of therapy should be determined by your doctor.

Administration

Santinal MR Capsule (Modified Release) 200 mg is usually taken orally with or without food, according to the instructions of a doctor. It is important to take the medication regularly and as prescribed in order to maximize its effects.

Side Effect

Common side effects associated with dipyridamole include nausea, vomiting, diarrhea, dizziness, headache, and low blood pressure. If these effects persist or worsen, contact your doctor or pharmacist promptly.

Toxicity

Overdose of dipyridamole may lead to serious side effects including arrhythmias, seizures, confusion, and coma. If you think you or someone else may have taken an overdose, seek medical attention immediately.

Precaution

Patients taking dipyridamole should not receive any aspirin products without first asking their doctor as this may increase the risk of serious bleeding. Also, it should not be used in pregnant or nursing mothers without first consulting with a doctor.

Interaction

Santinal MR Capsule (Modified Release) 200 mg may interact with other medications such as anticoagulants, antiplatelet drugs, cimetidine, cyclosporine, ketoconazole, and medications used to treat depression. It is important to tell your doctor all of the medications you are currently taking in order to avoid any potential interactions.

Disease Interaction

Santinal MR Capsule (Modified Release) 200 mg may increase risks for some people with bleeding disorders, heart rhythm problems, a history of GI bleeding, and a history of stroke. It should be used with caution in patients with kidney or liver disease.

Drug Interaction

Food Interactions

Santinal MR Capsule (Modified Release) 200 mg should be taken with food to increase its absorption. It should not be taken with high-fat or high-protein meals, or alcoholic beverages, as this may affect its effectiveness.

Pregnancy Use

Santinal MR Capsule (Modified Release) 200 mg is not recommended for use in pregnant women as there is not enough information available to determine its safety. All pregnant women should discuss any risk factors with their doctor before taking this medication.

LactationUse

It is not known if dipyridamole passes into breast milk, so it is not recommended for use in women who are breastfeeding. Women who are breastfeeding should consult their doctor before taking this medication.

Acute Overdose

Signs and symptoms of an overdose of dipyridamole may include confusion, coma, and seizures. If you suspect an overdose, seek medical attention immediately.

Contraindication

Santinal MR Capsule (Modified Release) 200 mg should not be used in patients with known hypersensitivity or allergy to the drug or its components. It should also not be used in patients with a history of bleeding disorders, heart rhythm problems, a history of GI bleeding, or a history of stroke.

Use Direction

Santinal MR Capsule (Modified Release) 200 mg should be taken as prescribed by your doctor or healthcare provider. Important things to remember are to take it on time, take it with food, and not to stop the medication abruptly as this may result in the increased risk of developing dangerous blood clots.

Storage Condition

Santinal MR Capsule (Modified Release) 200 mg should be stored in an airtight container at room temperature away from direct sunlight and moisture. It should also be kept away from children and pets.

Volume of Distribution

Santinal MR Capsule (Modified Release) 200 mg is distributed in a volume of 54-91 l/kg in humans. It is usually distributed to the liver and kidneys and to a lesser extent to the fatty tissues and red blood cells.